The following article describes a new technology based on a distributed system such as Blockchain and powered by machine learning algorithms. The NeuroChain technology is a fusion between Blockchain and machine Learning, and based on three pillars:- A decision maker : A Chain of Bots- A set of rules : the Decision Protocol (Proof of Involvement and Integrity & Proof ofWorkflow)- A network and media : the Pragmatic Communication Channels (adaptive communicationprotocol) and Learning ecosystem.A Bot is a short hand for a robot. In the current context, it is an Artificial Intelligence acting independently on a specific node in a network. They work thanks to machine learning algorithms on top of a protocol and a network. Their key aspects is that they work in association: a chain of Bots distributed in the network. An important aspect of a Bot is that it is “placed” on a node. The Bots act as validators of transactions and communicate between each other so as to guarantee security, transparency and decentralized infrastructure issues (e.g., double spending problem, byzantine generals problem, etc.). The decision protocol is founded on two mathematical tools: the Proof of Involvement and the proof of Integrity (PII). Therefore, the proof of involvement retraces the effort realized by this specific Bot on the network. This effort is measured by the entropy and the enthalpy (amount of value / internal energy) it holds. The idea is that an important Bot answers to important needs, and is therefore heavily charged. The proof of integrity describes how reliable this Bot is.